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POLtheta processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

(December 2023)

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In view of the highly potent nature of the constructs and the modular approach that relies on convenient synthetic methods utilizing therapeutically approved biomolecules, our method expedites the production of potent bispecific antibody constructs with tunable cell killing efficacy with significant impact on therapeutic properties

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The GGT enzyme breaks down oxidized glutathione (GSSG) to provide cysteine for de novo GSH synthesis