Abbreviations 7nAChRs: Alpha-7-nicotinic acetylcholine receptors A: Amyloid- AD: Alzheimers disease ASD: Autism spectrum disorder ACh: Acetylcholine Akt: Protein kinase-B Bax: Bcl-2-associated X protein Bcl-2: B-cell lymphoma-2 CNS: Central nervous system DhE: Dihydro--erythroidine GABA: Gamma-aminobutyric acid GSH: Glutathione GPX: Glutathione peroxidase Hg: Mercury IL-1: Interleukin-1 MDA: Malondialdehyde MLA: Methyllycaconitine NF-B: Nuclear factor kappa B Nfr2: Nuclear factor erythroid 2related factor 2 NO: Nitric oxide NDDs: Neurodevelopmental disorders NMDA: N -methyl-D-aspartate PI3K: Phosphoinositide 3-kinases PV: Parvalbumin ROS: Reactive oxygen species TNF-: Tumor necrosis factor-alpha WHO: World Health Organization References Hodges H, Fealko C, Soares N (2019) Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation
F., Guthmiller, J
It is known that BAs may regulate multiple physiological and pathological processes, implicating a role in the progression of NAFLD/NASH ( Bacteroides and Clostridium , which produced DCA accumulation in the feces, serum, and liver, and hepatic DCA led to sucralose-induced NAFLD in mice ( Accumulating studies have demonstrated that amino acids might play a role in the process of NAFLD/NASH, but the relationship hasnt been elucidated
Samples were agitated via vortex at 4 C for 30 min then centrifuged at 18,213 g for 10 min at 4 C
606 By activating autophagy and inhibiting ferroptosis, rapamycin reduces the loss of dopamine neurons in the substantia nigra and improves behavioral symptoms in PD model mice, suggesting that the mutual regulation of ferroptosis and autophagy may provide therapeutic targets for drug therapy of PD
San Diego: Academic Press
