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This article shows that PEGylation of the therapeutic protein interferon-2 increases lymphatic distribution and ultimately increases therapeutic efficacy against a lymph-resident cancer

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doi: 10.1016/j.chembiol.2018.02.010 188 KannappanVAliMSmallBRajendranGElzhenniSTajHet al

(4) vehicle/vehicle group: rats were given vehicle (isotonic saline, 1 ml/kg per day, i.p.) 5 min before water administration (5 ml/kg per day by oral gavage)

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Faded hyperpigmentation: Documented in Finkley 2005 as reduced mottled pigmentation, supported by GHK-Cus MMP-modulating activity