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Environmental factors, such as neurotoxins, pesticides, insecticides, dopamine (DA) itself, and genetic mutations in PD-associated proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation

Klein, B., Lu, Z.Y., Gaillard, J.P., Harousseau, J.L

AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer

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Abstract 42: lysosomal membrane permeabilization contributes to hyperglycemia-induced cardiomyocytes dysfunction

To model regions of RyR1 with poor density, x-ray crystal structures of the Ry12 and Ry34 domains were utilized with alternative conformations removed and Cys/Ala mutations reverted to the highest probability rotamers 51,52