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Its mainly produced in the body

A transcription repressor Zinc finger protein (ZNF704) associated with the SIN3 transcription regulator family member A (SIN3A) complex is overexpressed and amplified in cancers including breast cancer

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However, hyperuricemic patients with varying degrees of ABCG2 dysfunction, categorized by genotypes of dysfunctional SNPs, exhibit hyperuricemia characterized by urate overproduction

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Interestingly, residues that correspond to these catalytic sites in other analyzed sequences were found to be strictly conserved (Supplementary Figure S3)