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Future experiments will be needed to determine which type of TmGsts are implicated in antifungal drug detoxification and drug resistance

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This chemistry sits directly at the genome interface: transient, targeted oxidation events modulate transcription factors and chromatin modifiers (e.g., redox-sensitive cysteines in DNA-binding proteins or histone-modifying enzymes), enabling physiological control of gene expression (Juan et al

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Food Research International, 101 , 116

Furthermore, G4C2 repeat RNA and its translation product, dipeptide repeat protein, have been reported to cause neurodegeneration by increasing DNA double-strand breaks, leading to a deficiency of ataxia telangiectasia mutated (ATM), which repairs DNA damage [67]