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10.1016/j.bioorg.2013.11.004 107 OrdonezE.Van BelleK.RoosG.De GalanS.LetekM.GilJ

The unfolded protein response, the stress-induced quality control system of the endoplasmic reticulum, is activated not only by the accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum, but also by signaling lipids, including sphingolipids, and by the potentially harmful excess of lipid species such as saturated fatty acids, ceramides and cholesterol (Puth et al., 2015)

Suzuki et al., 1989

Recent research indicates that nutritional supplementation may play a valuable adjunctive role in PCOS management, particularly in addressing metabolic, hormonal, and inflammatory disturbances

The latter contributed to accumulated butyrate that acts as an HDAC inhibitor (172) and consequently as a tumour suppressor

Platinum resistance is broadly governed by two intertwined domains: cell-intrinsic mechanisms, such as enhanced DNA repair and altered drug metabolism, and tumor microenvironment (TME) influences, including stromal remodeling, immune suppression, and metabolic crosstalk