Abbreviations 95% CI: 95% Confidential interval AEs: Adverse events AIC: Akaikes Information Criterion ALT: Alanine aminotransferase aPTT: Activated partial thromboplastin time BHMT: Betaine-homocysteine methyltransferase BMI: Body mass index B12: Vitamin B12 CBS: Cystathionine beta-synthase CT: Computed tomography DHFR: Dihydrofolate reductase ECOG-PS: Eastern Cooperative Oncology Group performance status FA: Folic acid FN: Febrile neutropenia FPGS: Folylpoly--glutamate synthase G: Grade GGH: -Glutamyl hydrolase Hcy: Homocysteine HIBCH: 3-Hydroxyisobutyryl-CoA hydrolase HR: Hazard ratio LD: Linkage disequilibrium MPM: Malignant pleural mesothelioma MTHFR: Methylenetetrahydrofolate reductase MTR: Methionine synthase MTRR: Methionine synthase reductase NLR: Neutrophil to lymphocyte ratio non-Sq NSCLC: Non-squamous non-small cell lung cancer OR: Odds ratio OS: Overall survival PFS: Progression-free survival PS: Propensity score PT: Prothrombin time RBC: Red blood cell RBP: Retinol-binding protein ROC: Receiver operating characteristics SI: Smoking index SLC19A1: Folate carrier SNPs: Single-nucleotide polymorphisms Tf: Transferrin TTR: Transthyretin TYMS: Thymidylate synthase References Niyikiza C, Hanauske AR, Rusthoven JJ, Calvert AH, Allen R, Paoletti P, et al
Adults over 50 and vegetarians are more likely to suffer from B-12 deficiency, so B-12 injections may be ideal for older individuals trying to manage their health
Furthermore, the regular measurement of serum vitamin B12 concentrations in all patients at risk (e.g., people using metformin) may cause unnecessary costs in the long term, which needs to be weighed against the costs of vitamin B12 treatment
Bathroom: When getting up to use the bathroom, roll the IV pole into the bathroom using your non-IV arm
Too much pyridoxine could cause nerve pain in the hands and feet, loss of control of body movements (ataxia), and nausea
Epstein-Barr Virus : Causes infectious mononucleosis
