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Of note, many of the flavonoids contain a catechol group and can be easily oxidized by tyrosinase, as revealed earlier for quercetin which functioned as a tyrosinase substrate 87,88

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Heavy metals (lead): under 0.5 ppm (spec 1 ppm or less)

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MPP-modified DOX significantly enhances drug accumulation in mitochondria by 11.6 fold, resulting in a significant increase in ROS generation and a decrease in the production of ATP that can inhibit drug efflux and the growth of drug-resistant cancer cells (174)