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In PtGSTU19 and 20, glutathione binding induces two distinct stabilizations, 2 to 3 region for PtGSTU20 and 6 helix for PtGSTU19

doi: 10.1097/JES.0b013e318245837b

Primary antibodies used: mouse anti-FLAG (Sigma, #F1804) (1:600) and rabbit anti-HA-Tag (C29F4) (Cell Signaling, #3724) (1:700)

Journal of Fungi, 8 (2), 126

Conversely, serine deprivation triggers cellular stress and adaptive metabolic remodeling, and subsequently suppresses tumor progression ( de novo serine synthesis pathway has emerged as a central focus in the field of cancer metabolism research ( 3 Core roles of the de novo serine synthesis pathway in malignant tumors The serine synthesis pathway exerts multiple critical functions in cancer cells

Therefore, Gln deprivation-induced iron death in tumor cells may represent a novel therapeutic strategy for liver tumors ( Inhibiting Gln metabolism may serve as an effective anti-tumor strategy