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Recent studies have reported that ferroptosis is a significant factor in certain malignancies and degenerative disorders, including gliomas (13), triple-negative breast cancer (14), colorectal cancer (15), liver cancer (16) and kidney cancer (17)

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478 Immune-responsive nanoscale drug carriers, such as DOX-MSN-SS-iRGD&1MT nanoparticles, have been developed to codeliver chemotherapy and ICIs across the BBB

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