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The potential mechanisms by which VPA manifests its antimycobacterial activity include NO production and histone deacetylase 1 (HDAC-1) inhibition ( Figure 3 )

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A very important function of methylation is the conversion of homocysteine into methionine

Thus, dysfunctional carbonylated proteins accumulate as covalently crossed protein aggregates, making them highly resistant to proteolysis, thereby affecting the functional integrity of cells during the aging and disease processes