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Autophagy: a double-edged sword in intervertebral disk degeneration

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2013), pyroglutamic acid was increased at 24 h in both urine and serum from rats dosed with 1250 mg APAP/kg body weight

Interestingly, gene inhibition and CB-839, an inhibitor of GLS activity, can eliminate SREBP activation, suggesting that ammonia derived from GLS is a critical mediator of lipogenesis (90, 142)