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An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, et al

Although pharmacotherapy remains central to SLE management, current treatment strategies have limitations, such as inadequate response or side effects in some patients

Lahiri DK, Ge Y

However, the eNOS activity can be lost or even the enzyme can be uncoupled by oxidative stress (Daiber et al., Despite the fact that ROS are being generated at injured and inflamed sites, it has been shown that low levels of ROS have an important regulatory role as signaling intermediates that are essential for different cell activities such as cell adaptation and growth (Abid et al., Background and Physiological Relevance ROS and Reactive Nitrogen Species ROS are molecules with unpaired electrons in their outer orbit

Oxidative stress due to these free radicals containing unpaired electrons can damage cells and the DNA leading to several diseases and even cancers, dementia, Alzheimers disease, Parkinsons disease and coronary heart disease

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations