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Abstract Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes

To move Epitalon from experimental to evidence-based, several developments are essential: Randomized, double-blind, placebo-controlled clinical trials, ideally targeting specific endpoints (sleep, immune aging, telomere attrition) Toxicology and long-term safety studies, including exploration of stereoisomer effects and off-target consequences Validated delivery systems (e.g., dendrimer-conjugates, transdermal patches) that make real-world use feasible Pharmacodynamic biomarkers, to identify responders and track efficacy objectively over time Epitalon is not snake oil, but its also not a magic bullet

10.1016/S0959-440X(96)80036-4 9 FarnoodianM.HalbachC.SlingerC.PattnaikB

Chen H, Zhou J, Luo J, Wu Y, Qian Y, Shi Y, et al

After further culturing for 24 h, each well was washed, 1 mg mL 1 MTT solution (100 L) was added, and the cells were re-incubated for 4 h in the dark