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Why Are Peptides a Big Deal

doi: 10.1016/j.cell.2012.10.035 141 PirozziGTirinoVCamerlingoRFrancoRLa RoccaALiguoriEet al

Nat Commun 11(1):603, 2020

Within cells, GSH primarily exists in a reduced state, along with two interchangeable oxidized forms: the disulde form (GSSG) and a mixed disulde with protein thiols (GSSR)

The paper also highlights the role of oxidative stress and mitochondrial dysfunction in AD, as well as the dual role of p53 protein in DNA repair and apoptosis