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In general, without wishing to be bound to any theory, receptor-mediated transcytosis occurs in three steps: receptor-mediated endocytosis of the agent at the luminal (blood) side, movement through the endothelial cytoplasm, and exocytosis of the drug at the abluminal (brain) side of the brain capillary endothelium

However, to date there is no direct evidence demonstrating that topical retinoids clearly exert a sebo-suppressive effect

Long-term outcome and evaluation of organ function in pediatric patients undergoing haploidentical and matched related hematopoietic cell transplantation for sickle cell disease

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These suggest that rhGH treatment directly activates steroidogenesis in PLCs, which is consistent with the previous studies [35]

doi: 10.3390/ijms21103425 65 Feldt-RasmussenU