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World J Gastroenterol 21(14):4345 Zhang Z, Liu F, Ai F, Chen X, Liu R, Zhang C, Fang N, Fu T, Wang X, Tang A (2023) The efficacy and mechanism of vonoprazan-containing triple therapy in the eradication of Helicobacter pylori

This isoquinoline alkaloid usually accumulates in mitochondria and partially inhibits complex I, which raises the AMP: ATP ratio and transiently activates AMP-activated protein kinase (AMPK)