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335 As documented in this section and Table 3, antineoplastic agents/methods with ROS-inducing potential and their ROS-mediated antitumor mechanismscompiled from sources including the FDA database (www.fda.gov), ClinicalTrials.gov, and DrugBank ( diverse mechanisms of action ranging from metabolic interference to direct oxidative damage

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PRX6 is unique amongst the PRXs in that it lacks a resolving cysteine (C R ) and is multifunctional, additionally exhibiting both phospholipase, and PLA 2 activity 55

Alanine (Ala), the smallest chiral amino acid, serves as an ideal probe for alanine-scanning mutagenesis (Figure S2)