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Juan Piazze et al

This consideration may require additional diagnostic workup and/or referral to appropriate specialists

227,234,235 Collectively, sirtuins orchestrate an integrated modulation of metabolic pathways via NAD + -dependent post-translational regulation in response to diverse nutrient signals

Consequently, peptides encounter difficulties in reaching their cellular and matrix targets in adequate doses, leading to an inability to elicit meaningful biological responses and contributing to unsuccessful clinical trials