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GH secretagogue was developed for therapy in osteoporosis and muscle wasting, but the official manufacturing of Ibutamoren was discontinued due to a lack of effectiveness in clinical studies

Tesamorelin Tesamorelin is a stabilized GHRH analogue FDA-approved for lipodystrophy in HIV patients

Biomed Pharmacother 188:118197

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While this acute effect has been studied primarily in the context of cardioprotection research, any acute hemodynamic modulation carries theoretical safety implications in research models involving compromised cardiovascular function

Huang et al., 2022a