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The cation of 1 is methyl or ethyl

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doi:10.1152/ajpendo.2000.279.3.E501 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R

Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized