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Overall, SHMT plays important roles in various pathological conditions and participates in the occurrence and development of multiple cancers

Emerging clinical evidence indicates that serum CRP (human clinical study) is significantly increased in patients with DPN, 9193 while higher CRP level is inversely related to NCV ( P 0.8) in ROC analysis, supporting their potential use as non-invasive biomarkers

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In addition, the tricarboxylic acid cycle or electron transfer chain in the mitochondria can promote lipid ROS accumulation and is involved in cysteine-deprivation-induced ferroptosis [18]

Alterations in Antioxidant Defense Systems in Schizophrenia Clinical and preclinical investigations of the actions of antioxidative defense systems in the brain suggest several ways in which ongoing oxidative stress might impact the occurrence and course of schizophrenia

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