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Clinically, the plasma tryptophan level in patients with depression is decreased (Messaoud et al., 2019), and supplementation with tryptophan can improve their depressive symptoms (Gonzalez et al., 2021)

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This evidence suggest that defective ceramide metabolism might target mitochondria favoring neurodegeneration

In order to obtain homogeneity with respect to gender proportion and the range of ages, we selected approximately two women for every man in a range of ages above 30 years old