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The ectoenzymatic activity of CD38 is independent of its receptor functions [1] and leads to synthesis of cADPR and NAADP from NAD and NADP, respectively, thereby producing key secondary messengers that mobilize calcium from intracellular stores and regulate calcium signaling [4, 7,8,9]

First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization