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doi: 10.5603/fm.98624

J Conserv Dent 2010;13:22532

Protonation at the 2-Position The lowest energy S2 and O2 protonated structures calculated for [s 2 Urd+H] + and [s 4 Urd+H] + , S2A S2 and O2A S4 both display C2- endo sugar puckering with anti nucleobase orientations and S2HO2HO3 and O2HO2HO3 dual hydrogen-bonding interactions, respectively, providing stability through an ion-dipole interaction, although both are calculated to be more than 20 kJ/mol (B3LYP) and 17 kJ/mol (MP2) less stable than the calculated ground conformers

PMID: 27075906 [2] Sukumar N, Rafnsson SB, Kandala NB, Bhopal R, Yajnik CS, Saravanan P

Furthermore, patients treated with levothyroxine were excluded from this analysis, avoiding drug influences on the assessed measures