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This, however, does not demonstrate that these organelles do not participate in TNR dynamics, since their slow recycling kinetics (days) implies that only a handful of molecules will be found, at any given time, in compartments involved in rapid molecule sorting, as these endosomes

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HHXX, LZ and BC advised on the structure and content of the manuscript, figure and tables, and revised and finalized the manuscript.

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1.3 Transdifferentiation of glial cells towards neurons Neuron loss has always been a significant problem faced by various neurodegenerative diseases and injuries