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Moreau et al., 2018)

Thioredoxin and thioredoxin reductase in relation to reversible S-nitrosylation

No drug-linker mass shift was observed during this study (no premature exatecan release or metabolization), excepted the +18 Da (+H2O) mass shift from self-stabilizing hydrolysis of the maleimide group (which was complete after 48-72h ADC incubation time)