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Biol Psychiatry (2008) 63:82131.10.1016/j.biopsych.2007.10.022 116 TaylorKSSeminowiczDADavisKD

These strategies aim to break through the core contradiction of ferroptosis therapyhow to induce immunosuppressive M2 macrophage ferroptosis while avoiding tissue damage caused by excessive activation of pro-inflammatory M1 typeand provide a new paradigm for solid tumor immunotherapy

It is absorbed in the small intestine and enters the circulation, from whence it can provide a range of benefits

PLoS ONE 9 , e100286 (2014)

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However, unlike other members of the family, TGM2 is ubiquitously expressed and is secreted into the extracellular space (Chou et al., 2011