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Glutathione - A potent detoxifier and antioxidant

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

S., Umesaki, Y

PARP1 pathway Four PARP-1 domainsF1, F3, WGR, and CAT (catalytic)are crucial for DNA damage-dependent activity, whereas the CAT domain, comprising the Helical Domain (HD) and ADP-ribosyltransferase (ART), is vital for activation