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Although its acute (4-hour period) administration in overweight human subjects was associated with significant increase in energy expenditure (by ~8%) (216), a 28-day clinical trial investigating the efficacy of chronic use of L-796568 in overweight and obese non-diabetic men receiving the drug (350 mg/d) failed to display any significant changes in body composition or 24-hour energy expenditure (217)

Unlike opioids, it does not act on the brains pain receptors but instead targets inflammation at its source

J Clin Invest 128:36713681

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In laboratory research, administering 5-Amino-1MQ competitively inhibits NNMT activity, halting the clearance of nicotinamide