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These studies were supported by grants from the Agence Nationale de la Recherche (ANR-2010-BLAN-1415-01, ANR12BVS10032), Institut National de la Sant et de la Recherche Mdicale, Centre National de la Recherche Scientifique, Universit de Montpellier, Biocampus, IPAM-BCM and Rgion Languedoc Roussillon to P-FM and PM