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Description

Nature 472 , 476480 (2011)

Stability, dissolution, intestinal transport, metabolism and systemic exposure are separate questions

Y.HuB.WangT.CaiJ

RAW 264.7 cells were infected with wild-type LAC or the G4 mutant lacking four glucose transporters and treated with 40 M KL1 and 10 g/mL rifampicin (Rif)

In the next day, 9 l of the drug dilutions (BSO, Auranofin, BSO+Auranofin) were added to the wells so that every drug/combination was tested at 5 (fixed concentration ratio, for combinations) concentrations (1:3 serial dilution) in 2 replicates