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Activation of PGC-1 leads to an increase in mitochondrial content and function

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To date, the transdermal application of rotigotine is the best investigated dopaminergic treatment option: randomized, controlled trials showed a significant improvement of sleep disturbances [234], with increased sleep efficiency, shortened sleep latency and reduced nocturnal awakenings under rotigotine treatment [172]

Intravenous iron therapy is generally reserved for severe iron deficiency, although one study showed no difference in the efficacy of intravenous iron therapy compared to treatment with oral iron in the form of ferrous fumarate (Garrido-Martin 2012)