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10.1371/journal.pmed.1002522 81

Antifibrotics in chronic liver disease: tractable targets and translational challenges

Intracellular AGE accumulation is observed in animal models of hepatic steatosis and other advanced liver diseases, such as hepatic inflammation (steatohepatitis) and fibrosis/cirrhosis

Upon entering the small intestine, bile secretion increases the pH to a neutral or alkaline state, which reduces curcumins stability and solubility, further interfering with its absorption (95)