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It's a less severe concern than, say, copper toxicity, but it's a practical safety issue that must be considered

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Notably, histological analyses revealed that SYNCRIP expression was enriched in GBM tissues compared with lower-grade gliomas and normal brain tissues, suggesting a GBM-specific oncogenic role for SYNCRIP in tumor progression (Figure 1A-B)

Copper GHK supports many regenerative and reparative roles such as: Collagen and elastin synthesis* DNA maintenance* Healthy stem cell processes* Healthy inflammatory response* Neurological and cardiovascular health* Ingredients: See Label

Combining routes is also practiced: for example, topical GHK-Cu applied to the face while simultaneously using injectable GHK-Cu for systemic benefits