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However, this iron accumulation does not trigger iron-induced cell death

Inhibiting sEH has shown beneficial effects in a variety of age-related diseases such as diabetes (Lee et al., 2020

Elevated IL-33 levels in IBD patients correlate with disease severity, and aberrant f-IL-33 isoform localization in intestinal epithelial cells further exacerbates inflammation

Inactivation of GPX4 leads to an accumulation of lipid peroxides, resulting in ferroptotic cell death

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