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Specifically, HNE reportedly directly activates two members of the stress-activated kinase family, JNK and p38, in NT2 neuronal cells (198)

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Acta 1034 , 144152 (2018)

Mutants lacking either tAPX, sAPX or both in Arabidopsis showed symptoms of partial chlorophyll loss in tAPX mutants, and total bleaching in seedlings for the latter two plants

Carbonylation of the p46 and p54 isoforms of JNK kinase in human hepatic stellate cells activates activator protein 1 (AP-1), which stimulates the expression of procollagen type I, a fundamental step in liver fibrosis (83)