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Similarly, injection of BAPN combined with controlled exercise has been used to improve fiber alignment and reduce the risk of reinjury in adult horse tendons (Dyson, 2004), potentially through a similar mechanism relating LOX/LOXL4 and antifibrogenic phenotypes seen in the fibrotic skin models (Huang et al ., 2019)

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When combined dexamethasone and vitamin B12 was administered, upregulation of brain-derived neurotrophic factor (BDNF), glial cellderived neurotrophic factor, NT-3, and IL-6 were found in a rat sciatic nerve injury model 19

The risk of B12 deficiency is particularly relevant for patients following plant-based diets, those with existing digestive disorders, or individuals with genetic variants affecting nutrient absorption pathways