Nrf2 dissociates from Keap1 and is translocated from the cytoplasm to the nucleus to bind to the oxidative stress response site, promoting the expression of detoxifying enzymes, the antioxidant protein heme oxygenase 1, and anti-inflammatory enzymes
( In order to best assess behavioral alterations evaluated in toxin-induced or genetic models of PD, animal are usually submitted to tests such as (i) forced swimming test (FST) and (ii) sucrose-consumption test (SCT) which are both essentially designed to evaluate depressive behavior in rats and mice (Fontoura et al., 3.1.1 Forced swimming test (FST) The FST is one of the most used tests to evaluate depression-like behavior in mice and rats
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However, very intense or prolonged training without adequate recovery may increase oxidative stress, increasing the demand for antioxidants like glutathione
The amount of recovery and the results of these tests will help your team figure out whether surgery will be recommended
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