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(2009): Chronic fatigue syndrome and mitochondrial dysfunction

Cachexia can be explained by the presence of a negative energy balance, which is the result of low food intake due to the side effects of chemotherapy treatments, as well as altered orexigenic neuropeptide signaling, possible taste alterations, and increased caloric needs in tumor-bearing animals (11, 71)

An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures