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Bonner MR, Rothman N, Mumford JL, He X, Shen M, et al

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A bacterial endotoxin result on each lot shows the batch was screened for clean research handling

Both rapamycin (classical autophagy inducer) and RSL3 can block mechanistic target of rapamycin kinase (MTOR) activation and cause GPX4 protein degradation in human pancreatic cancer cells, which can restore or enhance the anticancer activity of gemcitabine in vitro or in xenogeneic PDAC models (Liu Y

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Annu Rev Pathol , 2013, 8: 241-276