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In addition to AD and PD/LBD, GRN variation has also been implicated in Gaucher disease [57], FTLD-TDP and/or motor neuron disease with C9orf72 repeat expansions [58], ALS [59], and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) [60]

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Citratpuffer sind geeignet, im pH-Bereich von 7 - 7,5 in Konzentrationen von 5 - 40 mMol/l zu stabilisieren.Citrate buffers are suitable to stabilize in the pH range of 7 - 7.5 in concentrations of 5 - 40 mmol / l

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This was first shown by adding NO donors to the isolated mitochondria (149, 150) and later by showing that NOS inhibition was associated with enhancement of oxygen consumption in the resting muscles of dogs and other organs (151, 152)