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NAFLD in children and adolescents is the most common cause of liver disease in this age group (Hatem et al., 2022) and is highly comorbid with childhood obesity (Shaunak et al., 2021)

This system is especially relevant for conditions involving mitochondrial dysfunction or redox imbalance, such as Leigh syndrome or cyclin-dependent kinase-like 5 ( CDKL5 ) deficiency disorder, where impaired OXPHOS, altered mitochondrial dynamics, and increased glycolytic reliance have been documented [12, 86, 87]

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rash or itching) or other hypersensitivity-type symptoms, but these are uncommon

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PLoS One 3:e1944, PMID: 18398470 Janky R, Ogita K, Pasqualotto BA, Bains JS, Oja SS, Yoneda Y, Shaw CA (1999) Glutathione and signal transduction in the mammalian CNS