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By genomic and metabolomics analyses of patients tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell lines we demonstrate that a fraction of metastatic ER + BC is highly reliant on oxidative phosphorylation (OXPHOS)

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In addition, another nonenzymatic process such as ROS-induced lipid peroxidation results in a variety of RCS and respective glycation products, demonstrating an interplay between oxidative and carbonyl stresses

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