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The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

One of the most prominent issues is related to the safety concerns in which techniques including focused ultrasound can cause damage to the surrounding and healthy tissues if the levels are not optimized and osmotic pumps may increase the fluid content, leading to the cerebral edema

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Int Immunol 1:367372 Erdo SL, Schafer M (1991) Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

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2 Materials and methods 2.1 Protein structures and evaluation The hMRP1 ( and hMRP7 ( structures were predicted using AlphaFold ( Evaluation of the AlphaFold predicted model protein structures was performed using pLDDT (predicted Local Distance Difference Test) (Sippl, 1993), ERRAT (Williams et al., 2018)) integrated within the SWISS-MODEL workspace (Waterhouse et al., 2018)