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In several multi-center longitudinal studies involving hemodialysis cohorts, the administration of IV Levocarnitine demonstrated a significant reduction in the ESA Resistance Index. Numerical data from recent trials indicates: Anemia Management: Patients receiving IV Levocarnitine showed an average 15% to 25% reduction in the required dose of Erythropoietin (EPO) to maintain target hemoglobin levels

Moreover, Sirius Red staining showed that the l-carnitine groups had decreased deposition of type I collagen fibers compared to the ACLT group (Fig

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[40] and Canbolat et al

In addition, L-carnitine caused higher glycogen deposition in the fasting state, and increased and decreased the mRNA expressions of gluconeogenesis-related and glycolysis-related genes, respectively