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The contribution of GHK versus 5-ALA to the observed effect cannot be isolated from this trial alone

Moreover, according to the glutamate-glutamine-GABA cycle, astrocytes release glutamine to neurons and inhibitory neurons convert it to GABA

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Researchers and clinicians using it do so based on extrapolation from animal data and accumulating clinical experience rather than proven efficacy in humans

NMR experimental data were processed using Topspin (Bruker) and analyzed using the POKY script 66

Both reasons are valid but the approach, expectations, and oversight should differ accordingly