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It is reasonable to assume that changes in CpG methylation levels in this region may reflect on the epigenetic landscape, possibly favoring the expression of CCL11

Disc herniation involves both mechanical factors (the displaced disc material) and biochemical factors (inflammation)

Since reticulocytes are nascent immature RBCs which are yet to undergo enzymatic glycation, the HbA1c values can be spuriously low in cases where there is spurt in erythropoiesis like this case where the Vit B12 deficiency was met by supplementation

This creates a feedback loop in which quality control informs biogenesis, ensuring a constant renewal cycle essential for cardiac homeostasis