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Cuproptosis can modulate the expression of key genes involved in ferroptosis regulation, such as glutathione peroxidase 4 (GPX4), by eliminating phospholipid hydroperoxides [123, 124] and acylcoenzyme A synthetase long-chain family member 4 (ACSL4) [125], thereby regulating the sensitivity of cells to ferroptosis inducers

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In addition, the mechanisms governing folate turnover and excretion are still poorly understood, at present

20 Bermano and coworkers 19 have observed that the C variant at the 3-untranslated region of the GPX4 gene was stronger than the T variant at driving biosynthesis of a selenoprotein reporter

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